Anthony Baptista 🔬

Anthony Baptista

(he/him)

Senior Postdoctoral Research Fellow

King's College London

The Alan Turing Institute

Professional Summary

I am a Senior Postdoctoral Research Fellow in Cancer Bioinformatics at King’s College London, working in the Grigoriadis group within the School of Cancer & Pharmaceutical Sciences. My research sits at the intersection of spatial transcriptomics, graph theory, explainable AI, and tumour microenvironment biology, with a focus on breast and liver cancer. I co-lead the KCL Spatial Biology Facility and co-organise the Alan Turing Interest Group on Topology and Geometry for Data.

Interests

Spatial Biology Multimodal Data Integration Biological Networks & Cancer Multilayer & Higher-order Networks Network Embedding & Random Walks Topological Data Analysis & Differential Geometry Geometric Deep Learning & Explainable AI
🔬 My Research

My work focuses on tumour microenvironments through the lens of spatial transcriptomics and network biology. I develop computational methods that integrate multi-modal spatial data, graph theory, and machine learning to map how cancer cells interact with their immune neighbourhood.

Current projects include the METABRIC-MX platform for multimodal breast cancer spatial analysis, the MOSAIK toolkit for cross-platform spatial transcriptomics integration, and a Cell-cell communications project establishing a mathematical equivalence between PDE-based models and random walk with restart on spatial graphs (details currently under NDA).

I’m always open to collaboration — feel free to reach out.

📣 Latest News
  • Jan 2026 — Awarded £10,000 DisCouRSE Flexible Fund for the SpatiaLondon Network project (with A. Vigilante, N. Matthews, M. Del Pilar Acedo Nunez, F. Ciccarelli, I. Sequeira).
  • May 2025 — Poster prize at the KCL School of Cancer & Pharmaceutical Sciences Annual Symposium.
  • 2024 — Co-PI on the OpnMe Innovation Grant from Boehringer Ingelheim (£80,000) for spatial transcriptomics of TLS maturity in TNBC.
  • 2024 — First place in the Alan Turing Institute Theory and Methods Challenge Fortnights call (£30,000) for the Geometry-Informed Data Representations workshop.
Featured Publications

A selection of recent work. See the full publications list for more.

Charting cellular differentiation trajectories with Ricci flow featured image

Charting cellular differentiation trajectories with Ricci flow

📖 _Nature Communications_ · 2024 — Using Ricci flow to chart cellular differentiation trajectories and reveal the geometric structure of gene expression landscapes during …

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Deep Learning as Ricci Flow featured image

Deep Learning as Ricci Flow

📖 _Scientific Reports_ · 2024 — A formal connection between deep learning dynamics and Ricci flow on Riemannian manifolds, giving a geometric framework for neural network training.

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SMART: A Spatio-Molecular Atlas of Response Trajectories in Triple-Negative Breast Cancer featured image

SMART: A Spatio-Molecular Atlas of Response Trajectories in Triple-Negative Breast Cancer

📖 _Nature Cancer (under review)_ · 2025 — A spatio-molecular atlas characterising response trajectories in triple-negative breast cancer using spatial transcriptomics and …

i.-wall
Mining higher-order triadic interactions featured image

Mining higher-order triadic interactions

📖 _Nature Communications_ · 2025 — A mathematical framework for mining higher-order triadic interactions in complex networks, showing how signed triadic relationships shape network …

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MOSAIK: Multi-Origin Spatial Transcriptomics Analysis and Integration Kit featured image

MOSAIK: Multi-Origin Spatial Transcriptomics Analysis and Integration Kit

📖 _Journal of Open Source Software_ · 2026 — Open-source toolkit for integrating spatial transcriptomics data from Xenium, CosMx and MERFISH into a standardised SpatialData …

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Projects
Cell-cell communications featured image

Cell-cell communications

A mathematical framework using walk with restart on spatial graphs.

MOSAIK featured image

MOSAIK

A toolkit for integrating Xenium, CosMx, and MERFISH spatial transcriptomics data into standardised SpatialData objects.

METABRIC-MX featured image

METABRIC-MX

Multimodal eXplorer for breast cancer spatial transcriptomics — integrating Xenium, metallomics, IF imaging, and H&E into unified SpatialData objects.